Lupin Breakthrough enables the return of (-)-sparteine

Copenhagen University Unlocks New Potential To Lupins

Lupins, a rising protein crop, are valued for their high protein content, making them a sustainable and nutritious option for human and animal consumption. However, new research has unveiled an exciting dimension to these versatile crops. A groundbreaking study led by Fernando Geu-Flores' research group at Copenhagen University demonstrates how lupins can be transformed into a powerful source of (−)-sparteine, a valuable, but limitedly available molecule in organic chemistry.

The Power of (−)-Sparteine

(-)-Sparteine is a key auxiliary alkaloid compound in chiral synthesis, a process critical for producing enantiomerically pure compounds in industries like pharmaceuticals and fine chemicals. Despite its potential, its variable price and limited availability have hindered large-scale adoption. This research marks a game-changing moment by creating narrow-leafed lupins (NLL) to accumulate large amounts of (-)-sparteine with remarkable purity (99% enantiomeric excess).

The Role of Our Technology

Using FIND-IT technology, we have identified and isolated a knockout mutation in the CYP71D189 enzyme in a bitter lupin library. This pathway increased (-)-sparteine accumulation to 96% of the total alkaloid content in lupin seeds. This discovery not only confirmed (-)-sparteine as the precursor to quinolizidine alkaloids (QAs) but also showcased the ability to enhance valuable metabolites in a crop without compromising yield and other plant traits.

Plants as Engines of Innovation

This discovery underscores the transformative power of plants as more than just sources of food. By leveraging the natural capabilities of lupins, researchers have unlocked a pathway to produce a high-value industrial compound sustainably and at scale. This achievement highlights the importance of collaboration between academic researchers and technology providers to drive innovation.

With a stable supply of consistent, high-purity (−)-sparteine now within reach, industries can begin to explore its full potential across a wide range of applications, paving the way for economic growth and technological advancement.

Partnering for the Future

We are proud to have played a pivotal role in this milestone achievement. This success story demonstrates the immense possibilities our technology can unlock in agriculture and industry.

For more details, you can access the publication HERE

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